Common and distinct circulating microRNAs in four neurovascular disorders
Rattachement africain : fi, us, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Familial cerebral cavernous malformations (FCCM), Sturge-Weber Syndrome (SWS), and hereditary hemorrhagic telangiectasia (HHT) are driven by genetic mutations causing varying vascular dysmorphism and risk of brain bleeding. Cerebral microbleeds (CMBs) are associated with the aging process with less characterized genetic drivers. This study hypothesizes that common and distinct circulating microRNAs (miRNAs) can reflect mechanisms of vascular dysmorphism and bleeding, which can serve as potential biomarkers in clinical contexts. Methods Differentially expressed (DE) plasma miRNAs ( p < 0.05, FDR corrected, absolute fold change [|FC|]>1.5]) were identified between patients with FCCM, SWS, HHT, and CMB, compared to age and sex matched healthy patients. Ingenuity Pathway Analysis as well as transcriptome integration analyses were performed to identify gene targets of the DE miRNAs and their associated pathways. Preselected miRNAs were validated using ddPCR. Results Eleven circulating DE miRNAs were identified in FCCM, 40 in SWS, 41 in HHT, and 26 in CMB ( p < 0.05, FDR-corrected, [|FC|]>1.5]). Further analyses showed that 18 DE miRNAs were commonly dysregulated in any two of the studied neurovascular disorders. The PI3K-Akt and ROBO SLIT signaling pathways were identified across all four disorders. The plasma levels of four miRNAs were further validated ( p < 0.05) using ddPCR. Conclusion The common dysregulated miRNAs across neurovascular disorders reflect shared mechanistic pathways underlying vascular dysmorphism and bleeding. These findings pave the way for further mechanistic exploration of these miRNAs, and their potential clinical application for disease monitoring and therapeutic intervention.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Common and distinct circulating microRNAs in four neurovascular disorders
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Turku University Hospital Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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University of Chicago Department of Neurological Surgery pays non établi dans la noticeUniversité ou école supérieure
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Northwestern University Department of Neurological Surgery pays non établi dans la noticeUniversité ou école supérieure
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Neurological Surgery pays non établi dans la noticeÉtablissement de santé
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University of Illinois Chicago pays non établi dans la noticeUniversité ou école supérieure
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St. Michael's Hospital pays non établi dans la noticeÉtablissement de santé
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University of California Department of Anesthesia and Perioperative Care pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois at Chicago Department of Neurology and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Neuro Repository pays non établi dans la noticeUniversité ou école supérieure
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University of Toronto St. Michael's Hospital pays non établi dans la noticeUniversité ou école supérieure
Department of Neurosurgery — Turku University Hospital, Department of Neurological Surgery — University of Chicago et Department of Neurological Surgery — Northwestern University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.