Perinatal Outcomes According to Treatment Targets for Gestational Diabetes: A Multi‐Centre Retrospective Cohort Study
Rattachement africain : us, au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Gestational diabetes (GDM) is currently diagnosed in approximately 18% of pregnancies in Australia. GDM may lead to infants being born large for gestational age (LGA), and other complications. There is currently no consensus on optimal treatment targets. AIMS: This study aims to compare perinatal outcomes in patients with GDM when treated according to tighter or less tight fasting blood glucose level (BGL) targets. METHODS: Our retrospective cohort study included data from all 12 metropolitan public hospitals providing maternity care in Victoria between January 2020 and December 2022. Women who gave birth to a term singleton infant and who had a diagnosis of GDM were included. Women were grouped according to their delivery hospitals' fasting BGL targets: 'tighter' (< 5.0-5.2 mmol/L) or 'less tight' (< 5.5-5.6 mmol/L). The primary outcome was LGA and a range of secondary outcomes were compared. Inverse probability treatment weights were calculated based on sociodemographic and socioeconomic factors. We then performed multilevel Poisson regression with delivery hospitals as random intercept. RESULTS: There were 25 041 births included, 12 423 (49.6%) in the 'tighter' target group, and 12 618 (50.4%) in the 'less tight' group. After adjusting for hospital and maternal demographics, there was no difference in LGA births (10.4% in 'tighter' vs. 9.5% in 'less tight' (p = 0.85)). More women received insulin treatment in the 'tighter' group (53%) compared to 'less tight' (35%, p < 0.001). There were no significant differences in secondary outcomes. CONCLUSION: Tighter fasting BGL targets were not associated with improved perinatal outcomes but were associated with an increase in pharmacotherapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Perinatal Outcomes According to Treatment Targets for Gestational Diabetes: A Multi‐Centre Retrospective Cohort Study
- Date Crossref
- 01/08/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Mercy Health pays non établi dans la noticeÉtablissement de santé
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The University of Melbourne pays non établi dans la noticeUniversité ou école supérieure
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Monash Health pays non établi dans la noticeÉtablissement de santé
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Royal Women's Hospital pays non établi dans la noticeÉtablissement de santé
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Western Health pays non établi dans la noticeÉtablissement de santé
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Sunshine Hospital pays non établi dans la noticeÉtablissement de santé
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Eastern Health pays non établi dans la noticeÉtablissement de santé
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University of Melbourne Melbourne Victoria Australia pays non établi dans la noticeUniversité ou école supérieure
Mercy Health, The University of Melbourne et Monash Health, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.