Real-World Toxicity and Effectiveness Study of Abemaciclib in Greek Patients with Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer: A Multi-Institutional Study
Rattachement africain : cy, gr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND/OBJECTIVES: This study aimed to assess real-world toxicity and efficacy data of patients with early and advanced breast cancer (BC) who received treatment with abemaciclib. METHODS: This was a prospective/retrospective multi-institutional collection of clinicopathological, toxicity, and outcome data from patients with early or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative BC who received treatment with abemaciclib in combination with endocrine therapy in departments of oncology in Greece. Treatment combinations of abemaciclib with any endocrine therapy were accepted. The primary end point was toxicity rate in all patients of the study. RESULTS: From June/2021 to May/2024, 245 women received abemaciclib/endocrine combination therapy; the median age was 57 years. Of these, 169 (69%) received abemaciclib as adjuvant therapy for early-stage disease, while 76 (31%) were treated for advanced BC. At the time of the data cutoff, 133 (84.7%) patients remained in the 2-year treatment period. The most common adverse event (AE) was diarrhea (51%), primarily Grade ≤ 2. Dose modifications due to AEs were required in 19.2% of cases, while treatment discontinuation occurred in 5.1%. There was no difference in dose modification/discontinuation rates between older patients (>65 years) and the remaining patients. For early-stage BC patients, the 2-year DFS and OS rates were 90.8% and 100%, respectively. In patients with advanced cancer (70, 30.8%), 1-year PFS and OS rates were 78% and 96.3%, respectively. CONCLUSIONS: This study confirms the safety and effectiveness of abemaciclib in alignment with registrational trials offering valuable insights into toxicity management and clinical outcomes in routine practice without identifying new safety concerns. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT04985058.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Real-World Toxicity and Effectiveness Study of Abemaciclib in Greek Patients with Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer: A Multi-Institutional Study
- Date Crossref
- 31/07/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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European University Cyprus Medical Oncology pays non établi dans la noticeUniversité ou école supérieure
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St. Luke's Hospital pays non établi dans la noticeÉtablissement de santé
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Metropolitan Hospital Second Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Hellenic Cooperative Oncology Group pays non établi dans la noticeEntreprise
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National and Kapodistrian University of Athens Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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St Savas Hospital pays non établi dans la noticeÉtablissement de santé
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Hygeia Hospital Second Department of Medical Oncology pays non établi dans la noticeÉtablissement de santé
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Limassol General Hospital pays non établi dans la noticeÉtablissement de santé
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Technological Educational Institute of Eastern Macedonia and Thrace pays non établi dans la noticeUniversité ou école supérieure
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Mitera Hospital pays non établi dans la noticeÉtablissement de santé
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IASO General Hospital pays non établi dans la noticeÉtablissement de santé
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Theageneio General Hospital pays non établi dans la noticeÉtablissement de santé
Medical Oncology — European University Cyprus, St. Luke's Hospital et Second Department of Medical Oncology — Metropolitan Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.