How Real‐Time Kinetics Explain the Different Interaction of Cubosomes and Hexosomes Nanoparticles with Lipid Membranes
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Le résumé fourni par la source
Abstract Cubosomes and hexosomes are interesting structures with diverse applications as drug and gene delivery systems, as well as theranostics. Understanding the uptake mechanism of these nanostructures by cell membranes is fundamental to improving and broadening their application. In this study, the kinetics of interaction of monoolein (GMO) cubosomes or dioleoylphosphatidylethanolamine (DOPE) hexosomes with supported lipid bilayers (SLBs) with varying compositions and stiffness, as valuable model membranes, are investigated by neutron reflectivity (NR) coupled with quartz crystal microbalance with dissipation monitoring (QCM‐D). Atomic force microscopy (AFM) is also used to analyze SLBs topography after such interaction. Cubosomes rapidly interact with SLBs, resulting in lipid exchange between the two systems, destabilizing the bilayer, and ultimately causing its removal. The inclusion of cholesterol (CHOL) in the SLB confers rigidity, making it more resistant to removal. Completely different results are obtained when hexosomes interact with SLBs: an intrinsic resistance of the bilayers toward these nanoparticles is observed, regardless of CHOL presence, combined with a slight change in SLB composition, suggesting that hexosomes tend to fuse with the SLB. These findings provide new and valuable insights into the potential mechanisms and kinetics of cellular uptake of these systems, enhancing their potential as drug delivery vectors.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- How Real‐Time Kinetics Explain the Different Interaction of Cubosomes and Hexosomes Nanoparticles with Lipid Membranes
- Date Crossref
- 31/07/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Rutherford Appleton Laboratory ISIS Neutron and Muon Source pays non établi dans la noticeStructure de recherche
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Italian Institute of Technology pays non établi dans la noticeStructure de recherche
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Marche Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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Materials Characterization Facility Istituto Italiano di Tecnologia Via Morego 30 Genoa 16163 Italy pays non établi dans la noticeInstitution
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Department of Science and Engineering of Materials Environment and Urban Planning – SIMAU Polytechnic University of Marche Via Brecce Bianche 12 Ancona I‐60131 Italy pays non établi dans la noticeUniversité ou école supérieure
ISIS Neutron and Muon Source — Rutherford Appleton Laboratory, Italian Institute of Technology et Marche Polytechnic University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.