Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes
Rattachement africain : cz, ru, de, pl, se. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Centromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore explain the unusual mitotic and meiotic behaviour of certain chromosomes, such as the germline-restricted chromosome (GRC) of songbirds. This chromosome is eliminated from somatic cells during early embryogenesis and later also from male germ cells during spermatogenesis. Although the mechanism of elimination is not yet known, it is possible that it involves a modification of the centromeric sequence on the GRC, resulting in problems with the attachment of this chromosome to the mitotic or meiotic spindle and its lagging during anaphase, which eventually leads to its elimination from the nucleus. However, the repetitive nature and rapid evolution of centromeres make their identification and comparative analysis across species and chromosomes challenging. Here, we used a combination of cytogenetic and genomic approaches to identify the centromeric sequences of two closely related songbird species, the common nightingale (Luscinia megarhynchos) and the thrush nightingale (L. luscinia). We found a 436-bp satellite repeat present in the centromeric regions of all regular chromosomes (i.e., autosomes and sex chromosomes), making it a strong candidate for the centromeric repeat. This centromeric repeat was highly similar between the two nightingale species. Interestingly, hybridization of the probe to this satellite repeat on meiotic spreads suggested that this repeat is missing on the GRC. Our results indicate that the change of the centromeric sequence may underlie the unusual inheritance and programmed DNA elimination of the GRC in songbirds.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes
- Date Crossref
- 30/07/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Charles University pays non établi dans la noticeUniversité ou école supérieure
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Institute of Molecular Genetics pays non établi dans la noticeStructure de recherche
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Czech Academy of Sciences pays non établi dans la noticeStructure de recherche
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European Molecular Biology Laboratory Genomics Core Facility pays non établi dans la noticeOrganisme public
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Adam Mickiewicz University in Poznań pays non établi dans la noticeUniversité ou école supérieure
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University of Bonn Bonn Institute for Organismal Biology-Animal Biodiversity pays non établi dans la noticeUniversité ou école supérieure
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Institute for Biodiversity pays non établi dans la noticeOrganisation à but non lucratif
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Leibniz Institute for the Analysis of Biodiversity Change Centre for Molecular Biodiversity Research pays non établi dans la noticeUniversité ou école supérieure
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Science for Life Laboratory pays non établi dans la noticeStructure de recherche
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Palacký University Olomouc pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Science Department of Zoology pays non établi dans la noticeUniversité ou école supérieure
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Laboratory of Genomics and Bioinformatics pays non établi dans la noticeStructure de recherche
Charles University, Institute of Molecular Genetics et Czech Academy of Sciences, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.