Recurrence Patterns, Treatment Outcomes, and Prognostic Factors of Thymic Carcinoma: A Multicenter Study
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Objectives: This multicenter study aimed to clarify the recurrence patterns; treatment outcomes; and prognostic factors of thymic carcinoma, a rare cancer. Methods: We analyzed 101 patients with thymic carcinoma who underwent multidisciplinary treatment, including radiotherapy. The median age was 62 years, with 27 patients in stage I–II; 44 in stage III; and 30 in stage IV by the TNM classification. Seventy-two patients underwent surgery with radiotherapy; and 29 patients underwent definitive radiotherapy. Image-guided radiotherapy (IGRT) and elective nodal irradiation (ENI) were used for 35 and 23 patients, respectively. Local recurrence-free survival (LRFS); progression-free survival (PFS); and overall survival (OS) were calculated, and univariate and multivariate analyses were performed. Results: With a median follow-up of 68 months, we observed 17 local recurrences; 27 regional recurrences; and 35 distant metastases. The 5-year LRFS; PFS; and OS were 82%, 41%, and 76%, respectively. Multivariate analysis revealed that stage was the only factor associated with LRFS; PFS; and OS (p = 0.040; p < 0.0001; and p = 0.048, respectively), while treatment modality was associated with only LRFS (p = 0.015). IGRT and ENI were also associated with LRFS (p = 0.002 and 0.013, respectively). PFS and OS of stage IV patients were comparable between the surgery with radiotherapy and definitive radiotherapy groups (p = 0.99 and 0.98, respectively). Conclusions: Our results suggest the importance of stage-specific treatment strategies rather than resectability, especially for stage IV patients. These results should be validated in a prospective study. Our results also suggest that radiotherapy methods influence recurrence
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Recurrence Patterns, Treatment Outcomes, and Prognostic Factors of Thymic Carcinoma: A Multicenter Study
- Date Crossref
- 30/07/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nagoya City University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Mizuho (Japan) pays non établi dans la noticeEntreprise
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Nagoya University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Mie University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Hamamatsu University School of Medicine Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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Aichi Medical University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Nagoya Medical Center pays non établi dans la noticeÉtablissement de santé
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Gifu University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Nagoya City West Medical Center Department of Radiotherapy pays non établi dans la noticeÉtablissement de santé
Department of Radiology — Nagoya City University, Mizuho (Japan) et Department of Radiology — Nagoya University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.