Potential of Corncob Extract on the Expression of Ki-67 and Caspase3 in Breast Cancer

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OBJECTIVE: The expression parameters of ki-67 and caspase3 in breast cancer model rats will be examined in this study to evaluate the effect of corncob extract administration on breast tissue of breast cancer animal model. METHODS: Twenty-one female Sprague Dawley rats were induced by DMBA. The experimental group was divided into three groups, after the formation of breast cancer experimental animals, the treatment group was given corncob, and the group of rats that were given 200 mg/kg BW of corncob extract and 250 mg/kg BW. The expression of ki-67 and caspase3 was evaluated using the immunohistochemical method. RESULTS: Corncob extract increased Caspase-3 expression in breast cancer experimental animals but did not significantly reduce Ki-67 expression in breast cancer in Spraque Dawley rats. CONCLUSION: Administration of corncob extract had an effect on caspase3 expression (as a marker of apoptosis) but had no effect on the expression of ki-67 (as a marker of proliferation.

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