Rutin-decorated molybdenum disulfide/hyaluronic acid methylprenyl hydrogel photothermal antibacterial therapy promotes skin wound repair

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Abstract This study aimed to develop a multifunctional hydrogel for skin wound healing by encapsulating rutin-modified molybdenum disulfide (MoS2) within methacrylated hyaluronic acid (HAMA). Rutin, a natural flavonoid, was employed to stabilize MoS2 dispersion and enable sustained release, thereby promoting fibroblast proliferation. Scanning electron microscopy revealed improved dispersion of rutin-modified MoS2 within the HAMA hydrogel matrix. Under near-infrared (NIR) irradiation, MoS2 demonstrated robust photothermal effects, significantly reducing bacterial viability of both Escherichia coli and Staphylococcus aureus. The sustained release of rutin synergistically enhances photothermal antibacterial efficacy while accelerating fibroblast proliferation, thereby facilitating skin wound healing. This dual-functional mechanism resolves the critical trade-off between rapid bacterial eradication and long-term tissue regeneration, offering a translational therapeutic strategy for wound repair.

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