A comprehensive review of antidiabetic activity of Malvaceae family plants

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Actuality.Recently, phytoproducts have gained major recognition as effective components in the complex treatment of chronic metabolic diseases, particularly diabetes mellitus.Plants from the Malvaceae family are a potential source of biologically active Фітотерапія.Часопис № 2, 2025 209 Біологія.Фармація compounds that was traditionally have been used in ethnomedicine in different countries for the correction of hypoglicemic states.A fundamental study of the antidiabetic properties of extracts from Malvaceae suggested their perspective for the pharmaceutical development of latest therapeutic and preventive drugs, including nanopharmaceutical products, which can be applicated into modern medical practice.The aim of the study was to analyze the scientific data on the antidiabetic properties of plants of the Malvaceae family and to evaluate their potential as a perspective raw source materials for phytotherapeutic agents in the treatment of diabetes mellitus.Material and methods to review of the scientific literature, including experimental and review articles, highlights the antidiabetic activity of the studied plants of each Malvaceae subfamily with a focus on their pharmacological properties and therapeutical potential for the diabetes mellitus.Research results.The results of a comprehensive analysis of scientific literature sources indicate that biologically active extracts and nanoparticles obtained from the representives of the Malvaceae family showed noticeable antidiabetic and hypoglycemic activity.The pharmacological action of these compounds is often attributes to the presence of polyphenols, particularly quarcetin, gallic acid, catechins, and other biologically active metabolites.The key mechanism of implementation of the antiglycemic effect is inhibition of the enzymes α-amylase, α-glucosidase, which regulate the modulation of carbohydrate metabolism and also prevent the excessive release of reducing sugars, which ensures stabilization of the glycemic profile.Conclusion.The relevance of further studies on pharmacokinetic parameters, molecular targets and safety of extracts and nanoformulation of plants of the Malvaceae in the treatment of diabetes mellitus.In particular, a perspective direction is the development of standardized phytocomplexes based on biologically active metabolites that provide prolonged glycemic action with minimal risk of side effects.Thus, the results of the analysis of scientific sources imply the significant therapeutic potential of reperesentative of the Malvaceae in the phytoterapy for the diabetes mellitus, which reveals new opportunities for the creation of effective and safe herbal medicines with proven mechanisms of action.

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