Exploring UBASH3A: from immune regulation to autoimmune diseases

Résumé fourni par la source

UBASH3A, also known as TULA or STS-2, is a lymphoid protein that has recently emerged as a novel regulator of T-cell activation and function. It used to be discussed as a member of the UBASH3/TULA/STS family to study the unique triple domain structure and protein‒protein interactions. In this review, we focus on the multifaceted regulatory roles of UBASH3A in biological processes within T cells. Furthermore, genetic variants in UBASH3A have been linked to at least five autoimmune phenotypes. Therefore, a broader understanding of the regulatory effects of UBASH3A in innate immunity and adaptive immunity could enable further improvements in the treatment of autoimmune disorders, antimicrobial therapy, and cancer immunotherapy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.