FIGURE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Le résumé fourni par la source
VDR ATAC-seq in AA and EA cell lines. A, ATAC-seq was undertaken in triplicate in HPr1AR, LNCaP, RC43N, and RC43T following 1α,25(OH)2D3 treatment (100 nmol/L, 4 hours) or vehicle control. FASTQ files were QC processed, aligned to hg38 (Rsubread), sorted and duplicates removed before further processing with ATACseqQC to generate nucleosome free and mononucleosome regions. Differential enrichment of regions was measured with csaw and the significantly different regions (Padj < 0.1) were then intersected to generate the Venn diagrams of overlapping regions by a minimum of 1 bp (ChIPpeakAnno). B, Motif enrichment in NF regions was undertaken with Homer and ranked by significance to visualize in descending significance. C, Frequency of enriched motifs by TF families’ class. D, Enrichment of circadian rhythm TFs.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- FIGURE 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
- Date Crossref
- 22/07/2025
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.