Immune Surveillance in the Peyer’s Patches of Mice After Acute High-Intensity Exercise
Rattachement africain : kr, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
PURPOSE: The immune surveillance theory in exercise immunology suggests that exercise redistributes immune cells to peripheral organs, including the gut. High-intensity exercise temporarily increases intestinal permeability, allowing the translocation of gut bacteria. This study investigated changes in phagocytes, T cells, and Th17 cell responses in Peyer's patches (PP), where access to gut bacteria is facilitated after acute intensive exercise in mice. METHODS: Mice underwent exhaustive swimming. Serum was obtained 1 h postexercise. PP was collected 0, 1, and 4 h postexercise. RESULTS: The exercise group exhibited elevated serum lipopolysaccharide levels compared with controls, indicating increased gut permeability. Alterations in immune cell composition and activation markers in PP were evident at 1 h but not immediately (0 h) postexercise. The proportions of dendritic cells (CD11c+) and macrophages (F4/80+) increased by 62% and 46%, respectively, whereas T (CD3+) and B cell (CD19+) proportions remained. Activation marker analysis revealed 48% and 25% higher frequencies of CD86-expressing cells among the CD11c+ cells and CD69-expressing cells among the T cells. Enhanced phagocytosis in PP cells was attributed to higher phagocyte proportions, not increased phagocytic capacity. Th17 cells increased by 72%, accompanied by upregulation of Th17-related genes, including IL-17F, IL-22, IL-23, CCL20, G-CSF, IFN-γ, and the immunoregulatory IL-10. T regulatory cell proportions and early inflammatory gene expression, including TNF-α and IL-6, showed no significant changes. CONCLUSIONS: Acute exercise activates phagocytes and T cells, triggering Th17 cell response in the PP. These results provide further evidence for the immune surveillance theory, highlighting the role of PP as a critical site for exercise-induced immune response.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immune Surveillance in the Peyer’s Patches of Mice After Acute High-Intensity Exercise
- Date Crossref
- 18/07/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Kyung Hee University Department of Biomedical Science and Technology pays non établi dans la noticeUniversité ou école supérieure
-
Bio-Medical Science (South Korea) pays non établi dans la noticeEntreprise
-
Gyeonggido Business and Science Accelerator Bio-Center pays non établi dans la noticeStructure de recherche
-
In-Q-Tel pays non établi dans la noticeOrganisation à but non lucratif
-
College of Sports Education pays non établi dans la noticeUniversité ou école supérieure
-
Gyeonggido Business & Science Accelerator Bio-Center pays non établi dans la noticeOrganisation à but non lucratif
-
College of Korean Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Humanitas College Hee Kang pays non établi dans la noticeUniversité ou école supérieure
-
Fax:+82-31-204-8106 pays non établi dans la noticeInstitution
-
Tel: +82-31-201-3493 pays non établi dans la noticeInstitution
Department of Biomedical Science and Technology — Kyung Hee University, Bio-Medical Science (South Korea) et Bio-Center — Gyeonggido Business and Science Accelerator, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.