Time Course of Symptoms in Normal-Pressure Hydrocephalus: A Systematic Review
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Le résumé fourni par la source
Background and Objectives: Idiopathic normal-pressure hydrocephalus (NPH) is a treatable, but diagnostically challenging condition in the elderly marked by gait disturbance, cognitive decline, and urinary incontinence. Ventriculoperitoneal (VP) shunting is effective, but the prognostic significance of symptom duration before surgery remains unclear. This systematic review evaluates symptom duration in NPH patients with postoperative outcomes. Methods: A systematic search of PubMed, Scopus, and Embase was conducted per PRISMA guidelines. Studies were included if they assessed clinical or radiological outcomes of VP shunting in adult NPH patients, reported symptom duration, and had a follow-up of at least one month. Clinical outcomes (MMSE, TUG, NPH score) were qualitatively analyzed due to study heterogeneity. Results: Twenty-four studies comprising 1169 patients were included (mean age: 72.45 years; mean symptom duration: 33.04 months). Most studies reported clinical improvement after VP shunting. However, few directly evaluated the effect of symptom duration, yielding inconsistent findings: some suggested better outcomes with shorter symptom duration, while others found no clear correlation. Larger studies often lacked conclusive data, and no randomized controlled trials were identified. Conclusions: VP shunting remains an effective intervention for NPH; however, evidence supporting the predictive value of preoperative symptom length is inconclusive. This review highlights the need for standardized diagnostic protocols and larger prospective studies to clarify this association and optimize surgical timing.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Time Course of Symptoms in Normal-Pressure Hydrocephalus: A Systematic Review
- Date Crossref
- 14/07/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Sarajevo Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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University of Zenica pays non établi dans la noticeUniversité ou école supérieure
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Sarajevo School of Science and Technology Sarajevo Medical School pays non établi dans la noticeUniversité ou école supérieure
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Philipps University of Marburg pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Cantonal Hospital Zenica Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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University Clinical Center Sarajevo Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Anatomy pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Marburg Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
Department of Neurosurgery — University of Sarajevo, University of Zenica et Sarajevo Medical School — Sarajevo School of Science and Technology, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.