Synthesis of a Phosphorous Sulfur Incorporating Reagent for the Enantioselective Synthesis of Thiophosphates

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Abstract In this chapter, the authors describe the procedure for the synthesis of a phosphorous sulfur incorporating reagent for the enantioselective synthesis of thiophosphates. They present some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The authors provide an evaluation of the potential hazards associated with phosphorous pentasulfide, 2,3,4,5,6‐pentafluorophenol, toluene, n‐heptane, methanol, dichloroethane, dichloromethane, triethylamine, (+) or (‐)‐limonene oxide, di‐n‐butyl phosphate, dichloroacetic acid and Celite, as well as the proper procedures for handling malodorous chemistry. Drawing inspiration from the oxathiaphospholane work originating with Stec, they develop the phosphorous‐sulfur incorporation reagents as a stable, and easily prepared reagent that links two entities affording a chiral thiophosphate with excellent levels of stereocontrol.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.