Clinical and Genetic Characteristics of Antiplatelet Therapy Resistance After Ischemic Stroke (Literature Review)
Rattachement africain : ru, bd. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Every year, 20 % of all ischemic strokes are recurrent, characterized by severe course and high mortality and disability rates. Secondary prevention measures are aimed at preventing repeated brain catastrophes, which leads to a 20–30 % reduction in the risk of recurrent stroke. One of the directions of therapy is the appointment of antiplatelet drugs. Currently, acetylsalicylic acid and clopidogrel are widely used in the Russia. Effective platelet inhibition by prescribing these antiplatelet agents is one of the priorities in the treatment of atherothrombotic ischemic stroke. At the same time, a number of patients develop resistance to antiplatelet agents, which is associated with a variety of factors, such as drug interactions, concomitant diseases, and genetic predisposition. In order to control the formation of laboratory resistance, several methods for assessing platelet function have been developed. For example, optical Born aggregatometry, thromboelastogram, flow cytometry. Currently, there is no “golden method” for determining the high residual activity of platelets, since none of them has achieved a significant advantage. This article discusses methods for detecting laboratory resistance and factors influencing its development, depending on the prescribed antiplatelet drug.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical and Genetic Characteristics of Antiplatelet Therapy Resistance After Ischemic Stroke (Literature Review)
- Date Crossref
- 06/07/2025
- Éditeur
- Ural State Medical University
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Regional Children's Hospital No1 pays non établi dans la noticeÉtablissement de santé
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Ural State Medical University Sverdlovsk Regional Clinical Hospital No. 1 pays non établi dans la noticeUniversité ou école supérieure
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Institute of Child and Mother Health pays non établi dans la noticeÉtablissement de santé
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Sverdlovsk Regional Clinical Hospital No. 1 pays non établi dans la noticeÉtablissement de santé
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Clinical and Diagnostic Center “Health Care of Mother and Child” pays non établi dans la noticeÉtablissement de santé
Regional Children's Hospital No1, Sverdlovsk Regional Clinical Hospital No. 1 — Ural State Medical University et Institute of Child and Mother Health, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.