White‐Light‐Induced Hydroxydifluoromethylation of Styrenes with Difluoroacetic Anhydride

Le résumé fourni par la source

Herein, a practical photocatalytic method is described for the hydroxydifluoromethylation of styrenes using readily available, easily‐to‐handle, and low‐cost difluoroacetic anhydride as CF 2 H source in the presence of simple acetoxime as the activator. The optimized conditions enable the reaction to proceed under mild white light, or even natural sunlight irradiation, yielding a range of β‐difluoromethylated alcohols in good yields. The gram‐scale synthesis and late‐stage modification of bioactive molecules further highlight its potential applications.

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