Gallbladder cancer in a young male: An insight into an integrative approach for improving survival

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ABSTRACT: A 30-year-old male presented with a mass in the gallbladder fossa infiltrating the liver, abdominal lymph nodes, port site lesion, and peritoneal nodularity, with a prior history of laparoscopic cholecystectomy. Cytology from the gallbladder fossa mass and port site intercostal lesion revealed features of adenocarcinoma. The patient was treated with six cycles of modified gemcitabine and oxaliplatin based chemotherapy, which resulted in complete metabolic response. The patient underwent extended cholecystectomy and wide local excision of the port site lesion. The patient had pathologic response with minimal microscopic residual disease of <1 mm size infiltrating liver. The patient received adjuvant chemoradiation. The patient is in remission at 4.1 years after the diagnosis of cancer. Resection with chemotherapy and radiotherapy can be considered if the metastatic lesions are isolated to prolong survival in gallbladder cancer.

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