A scoping review: POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder and Skin Changes), physical recovery, and rehabilitation

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ObjectivePOEMS syndrome is a rare and treatable plasma cell disorder. Although medical advances have improved survival, polyneuropathy - which impairs both sensory and motor function in the limbs - continues to be the predominant contributor to reduced mobility and quality of life. Multidisciplinary teams can offer rehabilitation during the disease progression and recovery, but there is limited guidance on appropriate types, intensity, and timing of intervention. This scoping review aims to answer the question: "What is known about physical recovery and rehabilitation in POEMS syndrome?"Data sourcesMEDLINE, CINAHL, EMBASE, PEDRO and EMCARE databases. Additional studies were identified from grey literature and handsearching of citations.Review methodsA scoping review was conducted. Included papers focused on POEMS syndrome with details on physical outcomes pre and post treatment and rehabilitation intervention. Data was extracted into tables, and a narrative summary was produced for each paper.ResultsIn total 21 papers were included and analysed through narrative summaries across three themes: 1) physical and functional deficits, 2) physical recovery and 3) rehabilitation interventions. There were no studies evaluating rehabilitation intervention and limited detail on intervention specifics and timings. Most studies focused on the outcome of medical intervention on physical impairments, with little attention to disability, function and quality of life.ConclusionsThere is a need for expert-led recommendations, standardised rehabilitation guidelines and further research into effective interventions including timing, intensity and the patient's preferences.

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