Obesity is associated with lower 30-day mortality in critically ill patients: A retrospective study of over 5400 patients

Résumé fourni par la source

BACKGROUND: , is associated with higher mortality in the general population but shows a complex relationship with chronic diseases and critically illness. The aim of this study was to determine whether BMI predicted 30-day mortality (primary outcome) and intensive care unit (ICU) and hospital lengths of stay (LOS) (secondary outcome) in critically ill patients. METHODS: ). The association between BMI and outcomes was assessed by multivariate Cox Lasso (Least absolute shrinkage and selection operator) or linear Lasso regression models, adjusted for age, sex, Simplified Acute Physiology Score (SAPS) II, primary diagnosis (ICD-10 codes) and measurement time points. RESULTS: (HR 1.44, p = 0.006) compared to normal weight. BMI categories in the overweight, obesity class I and class II range were all associated with longer ICU and hospital LOS (all p < 0.05). CONCLUSION: Patients with higher BMI, particularly with class II obesity, show a lower 30-day mortality in ICU settings, but a longer ICU and hospital LOS. This is likely a reflection of the obesity paradox and the complex role of body composition in critical illness outcomes. CLINICAL TRIAL REGISTRY: clinicaltrials.gov, identifier: NCT05834894.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.