Study of association and diagnostic utility of novel anthropometric and lipid indices for nonalcoholic fatty liver disease: A hospital-based study
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Le résumé fourni par la source
A BSTRACT Context: Given the prevalence of nonalcoholic fatty liver disease (NAFLD) of 25% and an expected prevalence of 55.4% by 2040 and its associated complications, it is essential to prioritize large-scale screening programs in the general population. Objectives: 1. To examine the association of the conventional and novel anthropometric and lipid indices in NAFLD and 2. To determine diagnostic ability, their cutoff values, and best parameter/model for detecting NAFLD. Settings and Design: A case-control study was done among 262 NAFLD cases and 186 non-NAFLD controls in a tertiary care hospital. Methods and Material: BMI, WC/Ht, LAP, VAI, TC, TG, HDL, LDL, VLDL, Non-HDL-C, TG:HDL-C, TC:HDL-C, LDL-C/HDL-C, TyG, CMI, RC, AIP, and AC were measured/calculated by recommended methods. Statistical Analysis Used: Binary univariate and multivariate logistic regression analyses and ROC analysis to determine the association, best statistical model, and diagnostic validity of study variables. Results: The individuals with BMI >30 had highest risk (OR = 9.636) of NAFLD followed by those with TG >500 mg/dl (7.054), LAPM (3.157) and LAPF (2.975), WC (M) (3.07), WC:Ht >0.6 (2.893), TyG (2.361), VAI-M (2.053), and VAI-F (2.253) in decreasing order. On ROC analysis, anthropometric parameters outperformed the lipid indices, among which BMI [AUC = 0.702; P < 0.001] and WC [0.671; P < 0.001] showed the highest AUC, followed by WC:Ht [0.657; P < 0.001]. Among lipid indices, LAP had the highest AUC [0.666; P < 0.001], followed by CMI [0.629; P < 0.001] and TyG [0.621; P < 0.001]. Conclusion: BMI, WC, LAP, WC/Ht, VAI, CMI, and TyG are the best simple and reliable indices for predicting/detecting NAFLD in the decreasing order of their diagnostic abilities which can identify the population at risk of NAFLD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Study of association and diagnostic utility of novel anthropometric and lipid indices for nonalcoholic fatty liver disease: A hospital-based study
- Date Crossref
- 01/06/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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All India Institute of Medical Sciences Raipur pays non établi dans la noticeUniversité ou école supérieure
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All India Institute of Medical Sciences Bhopal pays non établi dans la noticeUniversité ou école supérieure
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All India Institute of Medical Sciences Bibinagar pays non établi dans la noticeUniversité ou école supérieure
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All India Institute of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Biochemistry pays non établi dans la noticeInstitution
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Department of General Medicine pays non établi dans la noticeInstitution
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Department of Radio-diagnosis pays non établi dans la noticeInstitution
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Department of Community and Family Medicine pays non établi dans la noticeInstitution
All India Institute of Medical Sciences Raipur, All India Institute of Medical Sciences Bhopal et All India Institute of Medical Sciences Bibinagar, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.