Molecular characterisation of Mozambican patients diagnosed with colorectal adenocarcinoma

Résumé fourni par la source

Background: , and microsatellite instability (MSI) phenotype. Methods: platform and the levels of p53 protein by immunohistochemistry. Results: Our results, opposing to previous reports published on African or African descent populations, reveal a predominance of mutations in KRAS and overexpression of p53 protein, with much lower mutation frequencies in the remaining genes. Conclusions: Identification of the mutational pattern of Mozambican CRC patients can help Mozambican clinicians better optimise treatment planning and therefore patient's outcome. Promising results obtained in our study, allied to scarcity of molecular data from Mozambican CRC patients, make imperative to enlarge our patient sample set to obtain more clinicopathological data and demographic/ancestry information.

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