Impact of Intensive Blood Pressure Control on Cardiovascular and Cognitive Outcomes in Patients With Low Muscle Mass
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Le résumé fourni par la source
BACKGROUND: Intensive blood pressure (BP) control in patients with low muscle mass on cardiovascular (CV) and cognitive outcomes remains unclear. Therefore, we aim to examine the impact of intensive BP control on CV and cognitive outcomes in patients with low muscle mass. METHODS: Data from the Systolic Blood Pressure Intervention Trial (SPRINT) were utilized to estimate muscle mass. We employed Cox proportional hazard models and generalized linear models to explore how muscle mass status influences the efficacy of intensive BP control on both cardiovascular and cognitive outcomes on relative and absolute scales. Landmark analyses with cutoffs at 3.4 and 2 years assessed primary outcomes. RESULTS: Among 6,367 randomized participants, 469 (7.4%) had baseline low muscle mass. Intensive BP control resulted in a 5.2 events per 1,000 person-years reduction in absolute risk (hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.58-0.89) in patients with normal muscle mass. Conversely, it increased the absolute risk of primary cardiovascular events by 11.1 per 1,000 person-years in those with low muscle mass (HR, 1.72; 95% CI, 0.89-3.34; P = 0.013 for interaction), and led to a significantly higher rate of primary cardiovascular events compared to standard treatment after 3.4 years (P = 0.043). Regardless of the presence of low muscle mass, intensive BP control can reduce both the relative and absolute risks of cognitive outcomes, with all interaction P-values > 0.05. CONCLUSIONS: In persons with low muscle mass, intensive BP control was associated with an increased risk for CV events but not for cognitive decline.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of Intensive Blood Pressure Control on Cardiovascular and Cognitive Outcomes in Patients With Low Muscle Mass
- Date Crossref
- 27/06/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Beijing Friendship Hospital pays non établi dans la noticeÉtablissement de santé
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Academy of Medical Sciences Department of Cardiology pays non établi dans la noticeOrganisation à but non lucratif
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Peking Union Medical College Hospital Department of Allergy pays non établi dans la noticeÉtablissement de santé
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Academia Sinica pays non établi dans la noticeStructure de recherche
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Fu Wai Hospital pays non établi dans la noticeÉtablissement de santé
Department of Cardiology — Capital Medical University, Beijing Friendship Hospital et Department of Cardiology — Academy of Medical Sciences, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.