Association of gene methylation status RLEP, LEP, FTO, BDNF and COMT with risk factors for eating disorders in Mexican university students

Le résumé fourni par la source

Eating Disorders are complex conditions characterized by negatively impact a person's physical and mental health. Risky eating behavior are closely related to risk factors such as BMI, sex, depression, and anxiety. Aim The objective of this study is to determine the association of gene methylation status RLEP, LEP, FTO, BDNF, and COMT with the risk factors for eating disorders in Mexican university students. Methods An analytical cross-sectional study was carried out. Data on risky eating behavior, anxiety, and depression were collected using self-applicable questionnaires EAT, BAI, and BECK, respectively. The methylation of the genes was determined by MSP-PCR. Results We included 83 individuals, 61.4% women, and 38.6% men. Our results showed an association between the risk of eating disorders and anxiety and/or depression. When we determine the interaction between genes and risk factors, we find that the greater the number of risk variables, the greater the association of presenting risky eating behavior in Mexican university students. Conclusion We found an association between risk factors, especially depression and anxiety, with risky eating behavior in Mexican university students.

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