Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up
Rattachement africain : se, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Insulin resistance is a cardiometabolic risk factor characterized by elevated insulin levels. It is associated with fatty liver disease and elevated liver function tests (LFT) in cross-sectional studies, but data from cohort studies are scarce. AIM: To investigate the association between insulin and pathological LFT, liver disease, and cirrhosis in a population-based retrospective cohort study. METHODS: Anthropometric and cardiometabolic factors of 857 men and 1228 women from prospective cohort studies were used. LFT were obtained at two time points 8 years to 24 years after baseline. Liver disease diagnoses were obtained from nationwide registries. The association between insulin levels and the development of elevated LFT or liver disease and cirrhosis was analyzed. RESULTS: Total follow-up was 54054 person-years for women and 27556 person-years for men. Insulin levels were positively correlated with elevated LFT during follow-up, whereas physical activity and coffee consumption were negatively correlated. Individuals with both insulin levels in the upper tertile and alcohol consumption above MASLD thresholds had an increased risk for both liver disease, adjusted hazard ratio (aHR) of 4.3 (95%CI: 1.6-14.6) and cirrhosis (aHR = 4.8, 95%CI: 1.6-14.6). CONCLUSION: This population-based study provides evidence that high insulin levels are a risk factor for development of elevated liver enzymes and clinically manifest liver disease. The results support the concept of metabolic dysfunction associated liver disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up
- Date Crossref
- 27/06/2025
- Éditeur
- Baishideng Publishing Group Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Sahlgrenska University Hospital Transplant Institute pays non établi dans la noticeÉtablissement de santé
-
University of Gothenburg Department of Molecular and Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Uppsala University pays non établi dans la noticeUniversité ou école supérieure
-
MRC Prion Unit pays non établi dans la noticeStructure de recherche
-
University College London pays non établi dans la noticeUniversité ou école supérieure
-
University Uppsala Department of Public Health and Caring Sciences pays non établi dans la noticeUniversité ou école supérieure
-
UCL Institute of Neurology Department of Neurodegenerative Disease pays non établi dans la noticeStructure de recherche
Transplant Institute — Sahlgrenska University Hospital, Department of Molecular and Clinical Medicine — University of Gothenburg et Uppsala University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.