Development of home‐based methods to defat human milk for infants with chylothorax: An experimental study
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Le résumé fourni par la source
BACKGROUND: Chylothorax is a postoperative complication for infants with congenital heart defects; with high nutrition risk. Defatted human milk is recommended; however, refrigerated centrifugation to process milk poses accessibility barriers for many hospitals and families at home. Creation of a simplified home-based defatted milk protocol allows infants with chylothorax to be provided the immunological benefits of human milk postoperatively. METHODS: Milk from 20 mothers was tested to compare refrigerated centrifugation as the standard defatting technique against gravity-based methods: syringe tip-down and gravy separator. Two timeframes, 24 h and 48 h, were tested to determine if additional time had a significant impact on fat reduction. The MIRIS human milk analyzer provided results for fat, true protein, carbohydrate, and energy content. One-way analysis of variance was used to determine a significant difference on fat content among methods. RESULTS: All methods had a significant reduction in fat content, with centrifugation having the largest mean decline from 3.4 to 0.5 g/100 ml (P < 0.0001). The second most effective method to defat milk was 48-h gravy separator with a mean decline to 0.7 g/100 ml (P < 0.0001). Postpartum age of milk impacted the degree of fat removal in all methods. True protein content remained the same as baseline in all methods. CONCLUSION: A simplified home-based gravity separation method over 48 h reduced human milk fat by 80%. This is the first protocol to defat human milk without use of the more resource-intensive centrifugation method, that shows significant fat reduction with easy-to-use and accessible equipment for management of infants with chylothorax.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Development of home‐based methods to defat human milk for infants with chylothorax: An experimental study
- Date Crossref
- 23/06/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of British Columbia Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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BC Children's Hospital pays non établi dans la noticeÉtablissement de santé
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B.C. Women's Hospital & Health Centre pays non établi dans la noticeÉtablissement de santé
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BC Children's Hospital Research Institute pays non établi dans la noticeUniversité ou école supérieure
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British Columbia Children's Hospital Research Institute Vancouver British Columbia Canada Department of Critical Care pays non établi dans la noticeStructure de recherche
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Department of Critical Care British Columbia Children's Hospital Vancouver British Columbia Canada pays non établi dans la noticeÉtablissement de santé
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Department of Nutrition Services British Columbia Women's Hospital and Health Centre Vancouver British Columbia Canada Department of Nutrition Services pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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BC Women's Hospital and Health Center Vancouver British Columbia Canada BC Women's Provincial Milk Bank pays non établi dans la noticeÉtablissement de santé
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School of Population and Public Health pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics — University of British Columbia, BC Children's Hospital et B.C. Women's Hospital & Health Centre, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.