Endoscopic Submucosal Dissection Versus Laparoscopic and Endoscopic Cooperative Surgery for Superficial Duodenal Epithelial Tumors: A Multicenter Retrospective Study
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Le résumé fourni par la source
ABSTRACT Aims This study aimed to compare the clinicopathological features and short‐term outcomes of endoscopic submucosal dissection (ESD) and laparoscopic and endoscopic cooperative surgery (LECS) for superficial duodenal epithelial tumors (SDETs) and investigate the risk factors for severe adverse events (AEs). Methods Overall, 1017 patients who underwent ESD and 62 who underwent LECS to treat suspected SDETs between January 2008 and December 2018 were included. After comparing surgical and postsurgical outcomes between the two groups, logistic regression analyses were performed to identify the predictors of AEs. Results The lesion size was significantly larger in the LECS group than in the ESD group (28.5 vs. 20.8 mm, p < 0.01). The LECS group included significantly more patients with lesions greater than half the circumference than did the ESD group (19.3% vs. 5.4%, p < 0.01). LECS achieved a significantly higher complete closure rate of the resected wounds (98.4% vs. 74.4%, p < 0.01). Delayed bleeding and perforation occurred in 49 (5.0%) and 22 (2.2%) patients in the ESD group and 3 (4.8%) and 1 (1.6%) in the LECS group, respectively. Multivariate analyses revealed that incomplete closure of the resected wounds was the only independent risk factor for delayed bleeding (odds ratio, 5.069) and delayed perforation (odds ratio, 5.413). Conclusions Both ESD and LECS showed similar AE rates, although LECS is likely to be indicated for larger and wider circumferential tumors. Only incomplete closure of the resected wound was an independent risk factor for severe AEs, such as delayed perforation and bleeding.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Endoscopic Submucosal Dissection Versus Laparoscopic and Endoscopic Cooperative Surgery for Superficial Duodenal Epithelial Tumors: A Multicenter Retrospective Study
- Date Crossref
- 23/06/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Saku Central Hospital Department of Gastroenterological Surgery pays non établi dans la noticeÉtablissement de santé
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Keio University Center for Diagnostic and Therapeutic Endoscopy pays non établi dans la noticeUniversité ou école supérieure
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Osaka International Cancer Institute Department of Gastrointestinal Oncology pays non établi dans la noticeStructure de recherche
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Toranomon Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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National Cancer Center Hospital East Endoscopy Division pays non établi dans la noticeÉtablissement de santé
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Japanese Foundation For Cancer Research Department of Gastroenterology pays non établi dans la noticeOrganisation à but non lucratif
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Shizuoka Cancer Center pays non établi dans la noticeOrganisme public
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NTT Medical Center Department of Gastrointestinal Endoscopy pays non établi dans la noticeÉtablissement de santé
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Jichi Medical University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Jikei University School of Medicine Department of Endoscopy pays non établi dans la noticeUniversité ou école supérieure
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Ishikawa Prefectural Central Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Kyoto Prefectural University of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Gastroenterological Surgery — Saku Central Hospital, Center for Diagnostic and Therapeutic Endoscopy — Keio University et Department of Gastrointestinal Oncology — Osaka International Cancer Institute, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.