Bacteroides, Metabolites, and Lymphocytes: A Triad of Biomarkers in Small Intestinal Bacterial Overgrowth
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Le résumé fourni par la source
ABSTRACT The purpose of this study was to investigate the clinical characteristics of small intestinal bacterial overgrowth (SIBO) and analyze its relationship with changes in intestinal microbiota and metabolites. The study included patients from Beijing Shijitan Hospital (Feb 2021–Nov 2023) who underwent hydrogen‐methane breath tests, hematological tests, and completed questionnaires. Baseline characteristics of SIBO patients were analyzed using descriptive statistics and independent t‐tests. Logistic regression and Receiver Operating Characteristic (ROC) curve analysis identified potential SIBO predictors. Chi‐square tests assessed the association between SIBO and symptoms. Stool samples from 29 patients underwent 16S rRNA sequencing to analyze gut microbiota and metabolites. Then we explored links between microbiota, metabolites, symptoms, and serum markers. 405 persons in all completed the hydrogen methane breath test, of whom 109 (26.91%) were in the SIBO− and 296 (73.09%) were in the SIBO+. No significant differences were observed between the SIBO+ and SIBO− groups in terms of gender, age, or BMI. However, lymphocyte counts were significantly different between the groups, with lymphocyte count proving to be a better predictor of SIBO in middle‐aged and elderly non‐obese men. SIBO was significantly associated with diarrhea and acid reflux symptoms. 16S rRNA sequencing of stool samples from 29 patients revealed that Bacteroides was the predominant intestinal microbiota in SIBO patients. Metabolic pathways involving various metabolites were identified as significantly altered in these patients. Additionally, there were significant correlations between various intestinal flora and metabolites with serum markers.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bacteroides, Metabolites, and Lymphocytes: A Triad of Biomarkers in Small Intestinal Bacterial Overgrowth
- Date Crossref
- 01/06/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Gastroenterology Department pays non établi dans la noticeUniversité ou école supérieure
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Beijing Ditan Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing Shijitan Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing Tian Tan Hospital pays non établi dans la noticeÉtablissement de santé
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Zhumadian Central Hospital pays non établi dans la noticeÉtablissement de santé
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Peking University Shougang Hospital pays non établi dans la noticeÉtablissement de santé
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Design Institute Chinergy Limited Company Beijing China pays non établi dans la noticeStructure de recherche
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Shougang Hospital Peking University Beijing China Gastroenterology Department pays non établi dans la noticeUniversité ou école supérieure
Gastroenterology Department — Capital Medical University, Beijing Ditan Hospital et Beijing Shijitan Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.