Steroidomic Changes in the Cerebrospinal Fluid of Women with Multiple Sclerosis
Rattachement africain : cz, hk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Multiple sclerosis (MS) is a long-term disease that causes inflammation and damage to the nervous system. This study evaluated steroidomic alterations related to MS in 57 female MS patients during the follicular phase and 17 during the luteal phase, as well as in age- and phase-matched controls. The data showed that (1) unconjugated and conjugated steroids were strongly linked between the blood and CSF. (2) MS patients have lower levels of unconjugated steroids compared to controls. However, unchanged levels of conjugated steroids suggest a possible increase in steroid sulfotransferase functioning. (3) MS patients show altered levels of steroids linked to 11β-hydroxylase (CYP11B1) function. While direct enzyme activity was not measured, disrupted cortisol biosynthesis-potentially linked to reduced functioning of both CYP11B1 and 17α-hydroxylase/17,20-lyase-is associated with more severe cases of MS. (4) Reduced levels of 5α/β-steroids and protective GABAergic 3α-hydroxy-5α/β-steroids in MS patients might be linked to the pathophysiology of MS. (5) A potential increase in AKR1C3 function in MS could contribute to inflammation, as this enzyme catalyzes the synthesis of both steroids and prostaglandins. However, direct measurements of enzyme activity are needed to confirm this hypothesis. (6) Lower pregnenolone levels in MS patients might weaken neuroprotection, while higher pregnenolone sulfate levels could support cognitive function. (7) Lower levels of protective pregnenolone, DHEA, and androstenediol were associated with worse MS, suggesting these steroids may help shield against the disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Steroidomic Changes in the Cerebrospinal Fluid of Women with Multiple Sclerosis
- Date Crossref
- 19/06/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute of Endocrinology pays non établi dans la noticeOrganisme public
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Charles University pays non établi dans la noticeUniversité ou école supérieure
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Hospital Jihlava pays non établi dans la noticeÉtablissement de santé
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University of Hong Kong pays non établi dans la noticeUniversité ou école supérieure
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First Faculty of Medicine Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Jihlava Hospital MS Center pays non établi dans la noticeÉtablissement de santé
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Third Faculty of Medicine Department of Neurology 3FM CU and UHKV pays non établi dans la noticeUniversité ou école supérieure
Institute of Endocrinology, Charles University et Hospital Jihlava, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.