POS1195 OSTEOPOROSIS AND FRACTURES IN SYSTEMIC VASCULITIDES: A SYSTEMATIC REVIEW AND META-ANALYSIS

Le résumé fourni par la source

Background: Subjects with systemic vasculitides (SVs) are at heightened fracture risks, due to several risk factors. Objectives: We performed a systematic review and meta-analysis of observational studies aimed at investigating the prevalence of osteoporosis and osteoporotic fractures in subjects affected by SVs as well as to assess their risk of osteoporosis and osteoporotic fractures when compared to healthy controls. Methods: Scopus, Web of Science and PubMed were systematically searched from inception to December 2024 for observational studies investigating the prevalence of osteoporosis and fragility fractures in adults with SVs and the risk of prevalent osteoporosis and fragility fractures amongst those with and without SVs. Data from eligible studies were extracted, and meta-analysis was performed using a random effects model to obtain odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analyses, meta-regressions were also performed. This study was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/3G7RJ) Results: Forty studies with 23,358 individuals affected by SVs were included. The overall prevalence of osteoporosis and fragility fractures in the SV patients were respectively 14.64% (95%CI 12.21-18.89), and 17.08% (95%CI 11.42-24.78) (Figure 1). The ORs for osteoporosis and fragility fractures in SV patients when compared with controls was 2.92 (95%CI 1.72-4.98) and 2.39 (951CI 1.34-4.26) respectively (Figure 2). The univariable meta-regression analysis showed a significant association between cumulative glucocorticoids' dosage (total grams) and risk of prevalent osteoporosis (estimate = 0.0995, R2=0.24, p=0.0194). Conclusion: SVs are associated with an increased risk for osteoporosis and fragility fractures, suggesting that active vigilance and pre-emptive screening is recommended. REFERENCES: NIL . Acknowledgements: NIL . Disclosure of Interests: None declared . © The Authors 2025. This abstract is an open access article published in Annals of Rheumatic Diseases under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Neither EULAR nor the publisher make any representation as to the accuracy of the content. The authors are solely responsible for the content in their abstract including accuracy of the facts, statements, results, conclusion, citing resources etc.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.