A Photophosphorylation Nanobot for Restoring Anabolism of Myocardial Injury

Le résumé fourni par la source

Myocardial injury poses a significant obstacle due to the limited capacity for self-repair or dysfunction in ATP generation, leading to mortality risks worldwide. Here, we present a photophosphorylation nanobot capable of actively targeting therapeutics for myocardial injury in zebrafish larvae by accelerating the supply of ATP. Janus photophosphorylation nanobots are created through mechanical extrusion-assisted phase separation, forming asymmetric F o F 1 -ATPases embedded in a proteoliposome. Light-induced synergistic rotation of F o F 1 -ATPase significantly enhances the effective translational diffusion of nanobots by 89%, accompanying the photophosphorylation for generating ATP. The photophosphorylation nanobots display cell-like adaptive positive phototaxis motion and a phototactic swarm. These programmable phototactic nanobots can actively target the heart, improve intracellular ATP concentration to restore cellular metabolism, and finally repair myocardial injury. Such self-propelled and maneuverable nanobots that can actively modulate cellular energy metabolism in vivo hold considerable promise for advancing the targeted regulation of diseases associated with bioenergy metabolism in the future.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.