Macrolide Antibiotic Mediated Cardiac Arrhythmias: Emerging Concepts and Clinical Implications
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Le résumé fourni par la source
The macrolide class of antibiotics are widely utilized in clinical settings for a broad range of bacterial infections and have additional roles as immunomodulatory agents. Although efficacious with a good safety profile overall, they have been associated with prolongation of the QT interval and development of the polymorphic ventricular tachycardia, Torsades de pointes (TdP). In a 2020 scientific statement, the American Heart Association (AHA) classified azithromycin, clarithromycin and erythromycin as QT-prolonging drugs known to cause TdP and the online database, CredibleMeds, that maintains a list of drugs known to cause QT prolongation classifies these drugs as having an increased risk of QT prolongation. The mechanism of this risk has been delineated to involve macrolide binding to and a blockade of delayed rectifier potassium channels that conduct rapid potassium current, Ikr, during repolarization, leading to prolonged repolarization and subsequent QT prolongation. Studies investigating this association have revealed variable results, with several suggesting that the risk of QT prolongation and TdP with macrolide use may be highly dependent on underlying patient risk factors and comorbidities. In the present investigation, we summarize current evidence on association of macrolide antibiotics, azithromycin, clarithromycin and erythromycin, with the development of QT prolongation and TdP, pathophysiology of and risk factors predisposing to development of these events, the role of implementation of strategies to reduce this risk and highlight emerging research.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Macrolide Antibiotic Mediated Cardiac Arrhythmias: Emerging Concepts and Clinical Implications
- Date Crossref
- 16/06/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Texas Health Science Center at Houston Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Louisiana State University Health Sciences Center Shreveport Department of Anesthesiology pays non établi dans la noticeÉtablissement de santé
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University of Arkansas for Medical Sciences Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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University of the Pacific pays non établi dans la noticeUniversité ou école supérieure
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Thomas J. Long School of Pharmacy Department of Pharmacy Practice pays non établi dans la noticeUniversité ou école supérieure
Department of Internal Medicine — The University of Texas Health Science Center at Houston, Department of Anesthesiology — Louisiana State University Health Sciences Center Shreveport et Department of Pediatrics — University of Arkansas for Medical Sciences, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.