A time series analysis approach to quantify change in antibiotic resistance and antibiotic consumption during COVID-19 epidemics: a multicentre cross-national ecological study on behalf of QUantifying change in Antibiotic Resistance, ANTibiotic use, and INfection control during COVID-19 Epidemics study project
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Le résumé fourni par la source
OBJECTIVES: We aimed to assess the impact of COVID-19 on antibiotic consumption (AMC) and antimicrobial resistance (AMR) in the new epidemiological scenario from a cross-national perspective. METHODS: A quasi-experimental retrospective multicentre ecological study was conducted to explore the impact of COVID-19 on AMC and AMR using routinely generated retrospective time series data. This study included nine Healthcare University Hospitals from Europe and Israel on behalf QUantifying change in Antibiotic Resistance, ANTibiotic use, and INfection control during COVID-19 Epidemics project. Total effects were defined as the difference between the pre-COVID-19 period (ranging from January 2015 or January 2016 to February 2020) and during the COVID-19 pandemic period (March 2020 to July 2021 or December 2021). The outcomes were incidence density (ID) of carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Klebsiella pneumoniae, extended-spectrum beta-lactamase-producing Escherichia coli, vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus, carbapenem-resistant Pseudomonas aeruginosa and Clostridioides difficile, as monthly isolates per 1000 patient days and the monthly AMC ranked according to the Access, Watch, and Reserve WHO classification system. RESULTS: We assessed 15.9 million total hospital bed days, 315 736 COVID-19 bed days, 52 557 monthly bacterial isolates, and 461 739 monthly antimicrobial defined daily doses. The COVID-19 pandemic had a significant impact on the consumption of overall hospital antibiotics combined in all centres except two. Prescriptions for piperacillin/tazobactam, glycopeptides, and ceftazidime/avibactam increased, whereas third-generation cephalosporins, macrolides, and fluoroquinolones returned to pre-pandemic levels after an initial surge, in all centres. A positive relationship between the pandemic intensity and VRE ID was observed in 6 of 9 (66%) centres followed by methicillin-resistant S. aureus-ID and carbapenem-resistant P. aeruginosa-ID 3 of 4 (44%) for both. A negative relationship was found for extended-spectrum beta-lactamase-producing E. coli ID. DISCUSSION: The COVID-19 pandemic was associated with higher usage of broad-spectrum antibiotics and higher incidence of multidrug-resistant bacteria, with great variability by countries. These results could support international action plans that embed AMR as a priority in the post-COVID-19 era.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A time series analysis approach to quantify change in antibiotic resistance and antibiotic consumption during COVID-19 epidemics: a multicentre cross-national ecological study on behalf of QUantifying change in Antibiotic Resistance, ANTibiotic use, and INfection control during COVID-19 Epidemics study project
- Date Crossref
- 01/09/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Modena and Reggio Emilia Department of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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Instituto Murciano de Investigación Biosanitaria pays non établi dans la noticeStructure de recherche
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Hospital Vega Baja Medicine Preventive-Infection Control Team pays non établi dans la noticeÉtablissement de santé
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Azienda Ospedaliero-Universitaria di Modena pays non établi dans la noticeÉtablissement de santé
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Centre Hospitalier Universitaire de Besançon pays non établi dans la noticeÉtablissement de santé
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Southern Health and Social Care Trust pays non établi dans la noticeOrganisation à but non lucratif
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Rambam Health Care Campus Infectious Diseases Institute pays non établi dans la noticeÉtablissement de santé
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Rappaport Family Institute for Research in the Medical Sciences pays non établi dans la noticeStructure de recherche
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University Hospital Centre Zagreb pays non établi dans la noticeÉtablissement de santé
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University of Rijeka pays non établi dans la noticeUniversité ou école supérieure
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Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
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Sheba Medical Center pays non établi dans la noticeÉtablissement de santé
Department of Infectious Diseases — University of Modena and Reggio Emilia, Instituto Murciano de Investigación Biosanitaria et Medicine Preventive-Infection Control Team — Hospital Vega Baja, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.