596-P: Effects of a Very-Low-Calories Ketogenic Diet on Visceral Adipose and Muscular Tissues in Comparison with a Mediterranean Dietary Intervention

Le résumé fourni par la source

Introduction and Objective: Compared to a low caloric Mediterranean diet (LC-med), Very Low Calories Ketogenic Diet (VLCKD) obtains weight loss with a greater caloric deficit and an almost complete carbohydrates restriction that markedly reduces insulin secretion. We compared the impact of VLCKD and LC-med on visceral fat (VAT) and muscle loss. Methods: We studied prospectively 116 subjects who underwent LC-med, and 53 who underwent VLCKD. VAT was measured by ultrasound, Arm Muscle Area (AMA) by anthropometry. HOMA index was derived from fasting insulin and glucose concentrations. LC-med and VLCKD groups were, respectively, 70% vs 72% females, median (IQR) age 55 (44-65) vs 51 (46, 57) yrs, BMI 32 (28.8-35.2) vs 35 (31.5-39.2) kg/m², waist circumference 104 cm (98-113) vs 112 cm (101-122) cm, VAT 5.4 (3.38-6.88) vs 5.64 (3.53-7.32) cm and AMA 56 (47,68) vs 62 (51-76) cm². Results: The duration of intervention was similar but VLCKD reached more rapidly the -5% and the -10% weight loss targets. Nonetheless, at - 5% and -10% wt loss, VLCKD and LC-med lost similar amounts of VAT (-28% vs -41% and -69 vs - 64%) and of AMA (-3% vs -8% and -11% and -7%) from basal. VLCKD showed greater reductions in insulin at -5% wt loss (-23% vs -0%, p<0,001), in glucose concentration at -10% wt loss (-16 vs -3% p=0,045) and in HOMA at -10% wt loss (p=0.025). Conclusion: VLCKD is associated with a more rapid body weight reduction and to lower insulin concentrations compared to LC-med. Nonetheless, both treatments are equally effective in reducing visceral adipose tissue and in preserving muscle mass. Disclosure G. Pozzi: None. A. Foppiani: None. F. Sileo: None. S. Bertoli: None. A. Battezzati: None. Funding National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for proposals No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union NextGenerationEU; Award Number: Project code PE00000003, Concession Decree No. 1550 of 11 October 2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title ON Foods - Research and innovation network on food and nutrition Sustainability, Safety and Security Working ON Foods.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.