Abstract P3-01-28: Therapeutic Yoga Enhances Cognitive and Metabolic Markers in Breast Cancer Survivors

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Abstract Background: Cancer-related cognitive impairment (CRCI) frequently arises as a consequence of breast cancer treatments, manifesting in challenges such as impaired memory, attention, processing speed, and word finding. These cognitive deficits ranging from mild to moderate, can persist for months or even years. They can negatively impact a survivor's quality of life, mental health, and interpersonal relationships. Moreover, breast cancer and its therapies adversely affect various metabolic processes in the body influencing factors such as weight changes, fat metabolism, energy regulation, dyslipidemia, growth hormone regulation and cardiovascular health. This study aims to investigate whether a 16-week therapeutic yoga program (TYP) modulates the cognitive and metabolic biomarkers profile in plasma among heterogeneous breast cancer survivors. Approach: Participants included in the study were adults aged 18 and older with a clinical cancer diagnosis. Informed consent was obtained from all participants. Nineteen participants completed three weekly 75-minute sessions of TYP combined with love and kindness meditation. Blood samples were collected from sixteen participants both before and after the TYP intervention. Eight neuro and metabolic biomarkers viz, Beta-NGF, BDNF, Ghrelin, IL12P70, Leptin, MCP-1, TNF-Beta, VEGF-A were measured by a U-Plex Custom Metabolic Group1 (hu) Multiplex Assay on the MESO Quickplex SQ 120MM, Model 1300. The data was analyzed using Wilcoxen signed rank test. Results: The participants had a mean age of 59.6 years (± 7.3 years). Over half of the cohort (56%) were classified as overweight or obese (BMI ≥ 25 kg/m2). The majority were female (71%) and breast cancer survivors (65%), with 44% of these survivors being of Hispanic ethnicity. Statistically significant increases were observed in concentrations of BDNF (pre: 653.50 vs post: 1234.17 pg/ml; 88.85%, P=0.005) and ghrelin (pre: 576.10 vs post: 710.80 pg/ml; 23.38%, P=0.04). Notably there was a marked difference found [PDI1] in VEGF-A (45.51% increase post TYP) and MCP-1 (19.79% decrease post TYP). Conclusion: TYP contributed to substantial improvements in cognitive biomarkers in plasma samples from breast cancer patients. Future research utilizing larger cohorts is needed to validate these results. Citation Format: Minal Sonawane, G. J. Almeida, N. T. Darby, M. C. Serra, T. Calderon, A. Lapetoda, B. Gutierrez, A. G. Ramirez, D. C. Hughes, Darpan I. Patel. Therapeutic Yoga Enhances Cognitive and Metabolic Markers in Breast Cancer Survivors [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P3-01-28.

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