Childhood Obesity as a Predictor of Adult Physical/Functional Mobility; a Protocol for Systematic Review and Meta-Analysis.

Le résumé fourni par la source

Background Childhood and adolescent obesity is a global public health concern. Systematic reviews have linked it to short-term complications 1 during childhood and various long-term health issues in adulthood, including cardiovascular disease, cancer, renal disorders, adult obesity, and type 2 diabetes 2–6 . While evidence suggests musculoskeletal impairment in childhood and adolescence, data on its association with adult joint problems, pain, arthritis, impaired mobility, and physical disability remain limited. To address this gap, a systematic review is needed to examine the relationship between paediatric/adolescent obesity and the risk of impaired physical or functional mobility in adulthood. Aim and objective The primary objective of this systematic review is to explore whether childhood overweight/obesity is an independent predicator of impaired musculoskeletal health, physical function or mobility in adulthood. Methods This protocol is reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. This review will include peer-reviewed observational studies (longitudinal and cohort) published between January 1994 and October 2024. Multiple databases will be searched (MEDLINE, Pubmed, Embase, and CINAHL), using medical subject heading (MeSH) terms and relevant keywords. Study screening (title, abstract, full text) will be carried out independently by two researchers. The Risk of Bias in Non-Randomized Studies of Exposure (ROBINS-E) tool will be used to assess included studies, while the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework will evaluate evidence quality. Meta-analysis will be conducted. Statistical analyses will be performed using Stata 17. Results This systematic review will be completed by June 2025. Literature searches was conducted following registration of the review in PROSPERO (CRD42024627371). Conclusion Results will build understanding regarding childhood factors that should be addressed in order to minimise impaired musculoskeletal health, physical function or mobility in adulthood.

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