Weight loss is associated with improved daytime time in range in adults with prediabetes and non‐insulin‐treated type 2 diabetes undergoing dietary intervention

Résumé fourni par la source

Abstract Aims To characterize changes in continuous glucose monitoring (CGM)‐derived time in tight range (TIR) measures in individuals with prediabetes or non‐insulin‐treated type 2 diabetes undergoing dietary weight loss intervention and to quantify the association between weight loss and TIR improvement. Methods Data from the Personal Diet Study, a 6‐month behavioural weight loss intervention in adults with prediabetes or non‐insulin‐treated type 2 diabetes [HbA 1c ≤ 8.0% (64 mmol/mol), managed with diet alone or with metformin], was analysed. Participants wore a CGM for a maximum of 2 weeks at baseline and 6 months. Changes in overall, daytime (06:00 h–23:59 h) and overnight (00:00 h–05:59 h) time in 54–140 mg/dL or 3.0–7.8 mmol/L (TIR 54–140 ), 70–140 mg/dL or 3.9–7.8 mmol/L (TIR 70–140 ) and >140 mg/dL or >7.8 mmol/L (TAR >140 ) were analysed. The association between weight change and TIR change adjusted for demographic and clinical covariates was computed using linear regression. Results Baseline and 6 months CGM data from 76 participants (63 ± 8 years, 62% female, 64% White, BMI 33 ± 5 kg/m 2 , HbA 1c 5.8 ± 0.6%) were analysed. Overall TIR 54–140 increased (3.3% [0.3, 6.3]%; p = 0.03), with improvement in daytime (3.8% [0.9, 6.8]%; p = 0.01) but not overnight TIR 54–140 (2.0% [−2.2, 6.1]%; p = 0.36). In adjusted analysis, every 5% points of weight loss was associated with a 3.2% points increase in overall TIR 54–140 ( p = 0.016), driven by a 3.5% points increase in daytime TIR 54–140 ( p = 0.006). Similar associations were found for TAR >140 but not TIR 70–140 . There were no associations between weight loss and change in any overnight TIR measure. Conclusion Weight loss was associated with improved daytime TIR 54–140 and TAR >140 in individuals with prediabetes and non‐insulin‐treated type 2 diabetes undergoing dietary intervention. The daytime time in tight range measures can complement traditional markers like HbA1c, offering a more comprehensive view of glycaemic variations during dietary weight loss programmes for individuals with prediabetes and type 2 diabetes not on insulin.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.