Risk stratification of net adverse clinical events using CHADS-P2A2RC and CHADS2 scores in chronic coronary syndrome patients without atrial fibrillation: Insights from the CLIDAS-PCI
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Le résumé fourni par la source
Background There are few data verifying the utility of the CHADS-P 2 A 2 RC score in comparison with the CHADS 2 score for estimating net adverse clinical events (NACE) in chronic coronary syndrome (CCS) patients without atrial fibrillation (AF) in real-world settings. Methods We performed analysis for a total of 3985 CCS patients without AF who underwent percutaneous coronary intervention (PCI) between April 2013 and March 2019 for whom information was obtained from the CLIDAS (Clinical Deep Data Accumulation System)-PCI database. The primary endpoint was NACE defined as the composite of 3-point major adverse cardiovascular events (3P-MACE) (cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) and GUSTO moderate/severe bleeding events. Results Kaplan-Meier analysis showed that both the CHADS-P 2 A 2 RC and CHADS 2 scores stratified the risks. The incidences of NACE were stratified well by the very-high-risk category, which was uniquely defined as a CHADS-P 2 A 2 RC score of ≥6 (hazard ratio: 2.38, 95 % CI = 1.91–2.97, p -value <0.001). The area under the curve (AUC) in estimating NACE within 3 years was higher when the CHADS-P 2 A 2 RC score was used than when the CHADS 2 score was used (0.67 vs. 0.62, p = 0.003). This was mainly due to the accuracy in estimating bleeding events (0.66 vs. 0.60, p = 0.006). Conclusions The accuracy in estimating NACE after PCI for CCS patients without AF was higher when the CHADS-P 2 A 2 RC score was used than when the CHADS 2 score was used, mainly due to the accuracy in predicting bleeding risk. Higher incidences of endpoints were well-stratified by a very-high-risk category defined as a CHADS-P 2 A 2 RC score of ≥6.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Risk stratification of net adverse clinical events using CHADS-P2A2RC and CHADS2 scores in chronic coronary syndrome patients without atrial fibrillation: Insights from the CLIDAS-PCI
- Date Crossref
- 01/10/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osaka City University pays non établi dans la noticeUniversité ou école supérieure
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Kyushu University Department of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Jichi Medical University Department of Clinical Informatics pays non établi dans la noticeUniversité ou école supérieure
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University of Tokyo Hospital Department of Cardiovascular Medicine pays non établi dans la noticeÉtablissement de santé
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Development Bank of Japan pays non établi dans la noticeInstitution
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Tohoku University Department of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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National Cerebral and Cardiovascular Center pays non établi dans la noticeÉtablissement de santé
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Kumamoto University pays non établi dans la noticeUniversité ou école supérieure
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Jichi Medical University Saitama Medical Center pays non établi dans la noticeÉtablissement de santé
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Osaka Metropolitan University Graduate School of Medicine Department of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Cardiovascular Medicine pays non établi dans la noticeInstitution
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Open Innovation Center pays non établi dans la noticeInstitution
Osaka City University, Department of Cardiovascular Medicine — Kyushu University et Department of Clinical Informatics — Jichi Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.