Adiposity and Cardiometabolic Health Among Inuit of Nunavik: A 13-Year Follow-Up Study

Le résumé fourni par la source

Background Obesity (BMI ≥ 30 kg/m 2 ) is a major determinant of cardiometabolic health, yet the clinical impact of weight changes on cardiometabolic health in the Canadian Inuit population remains unclear. Method Data were collected from 302 individuals (107 men and 195 women) who participated in the Qanuippitaa? 2004 and 2017 Nunavik Inuit Health surveys. Anthropometric indices [weight, body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR), percentage of body fat (% BF) and free fat mass], metabolic biomarkers, and hemodynamics were measured. Anthropometric characteristics and cardiometabolic risk factors were compared between 2017 and 2004 using Student's paired t -tests or Chi-square test, adjusted for medication. The impact of adiposity changes on cardiometabolic risk factors (blood pressure, lipid profile and glucose homeostasis parameters) was assessed using adjusted multivariate regression linear analysis. Results Inuit men and women (mean baseline age: 37.1 and 36.4 years) showed a significant increase in age-standardized %BF, despite similar BMI in 2004 and 2017. Inuit women had significant rises in age-standardized WC and WHtR (p<0.05), while men's remained stable. Increased abdominal fat was linked to adverse changes in some lipid (HDL-C, Total C/HDL-C ratio, apolipoprotein B) and glucose homeostasis (HOMA-IR) parameters (p<0.05), but not LDL-C, triglycerides, non-HDL-C, fasting glucose, or blood pressure. Conclusion Adiposity phenotypes and cardiometabolic risk factors are evolving among Nunavik Inuit, but increased abdominal fat is not linked to certain lipid parameters, fasting glucose, or blood pressure. Further research is needed to understand ethnic-specific traits and improve weight-related complication management.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.