Chemical Profiles and Anti-Inflammatory Activities of the Copal Resin and Its Volatile Fraction of Bursera bipinnata

Résumé fourni par la source

Bursera bipinnata is known as “copal chino, is a small tree that grows in steep areas and is part of the transitional populations of pine and oak forests and lowland deciduous forests. It is the taxon with the widest geographic distribution in México and considered a source of high-grade copal resin used in ceremonies and offerings. Also, B. bipinnata is considered to have great value in traditional medicine to treat ailments related to in-flammation. In this work, the anti-inflammatory effects of the volatile fraction and resin of B. bipinnata in LPS-stimulated RAW 264.7 macrophage cells were demonstrated. The resin extract was the best inhibitor with a 65.83 ± 8.53 % of inhibition of NO production with IC50 = 30 ± 3.3 µg/mL. In contrast, its volatile fraction showed a 37.43± 7.13 % of inhibition at 40 µg/mL. GC/MS and LC analysis of the total resin allowed the chemical characterization of eleven pentacyclic triterpenes with ursane, oleanane, and lupane skeletons, and eight monoterpenes. The structures of compounds (15, 17, 29-35) are reported for the first time from the resin of Bursera bipinnata. The anti-inflammatory activity of the most abundant constituents of the resin of B. bipinnata (α-amyrin (15), 3-epilupeol (17) and α-phellandrene (1) has been previously demonstrated which con-firms the activity showed by the resin as well as the traditional use of this important copal resin. The chemical profile of B. bippinata differs from that of other copal resins (e.g. B. copallifera) in the presence of a greater variety of triterpenes in the resin.

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