Advancements in molecular techniques impacting the diagnostic landscape for dengue in the near future

Le résumé fourni par la source

Denue viral epidemics have escalated worldwide, with over 100 million infections occurring annually. The spread of the mosquito vector is supported by the increase in urbanization and climate change with models predicting potential impact of 6.1 billion people by 2080. Dengue is a mosquito borne viral infection caused by dengue virus, the genus of which contains four serotypes. While this virus causes mild infections with flu-like illness, it can occasionally develop into a potential lethal complication called severe dengue. There is currently no specific treatment but early detection and access to proper medical care can lower the fatality rates to below 1%. Currently prevention and control depend on stringent effective vector control measures with the help of community participation. Out true understanding of the circulation, transmission dynamics, immunological interactions, and association of genetic and antigenic diversity with severity remains limited. Thus the approach to investigate dengue virus epidemiology, immunological interactions, and genetic diversity using highly specific diagnostic and pathogen sequencing methods is crucial and requires developing integrated, targeted and effective intervention strategies. This paper explores current and emerging molecular methods and their anticipated impact on the diagnostic landscape for dengue in the near future.

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