Prospective Association Between Sarcopenia and Long-Term Risk of Hospitalization for Infection: A Cohort Study

Le résumé fourni par la source

OBJECTIVES: The relationship between sarcopenia and the long-term risk of hospitalization for infectious diseases is unclear. This study aimed to evaluate this relationship using a large prospective Caucasian cohort from the UK Biobank. DESIGN: This is a large prospective cohort study. SETTING AND PARTICIPANTS: Using the UK Biobank data, participants were assessed for handgrip strength and appendicular lean mass at baseline and categorized into the non-sarcopenia, probable sarcopenia, and sarcopenia groups. A total of 243,097 participants (mean age, 55.64 years; 52.7% female) were enrolled in this study; 12,982 (5.3%) had probable sarcopenia and 312 (0.1%) had sarcopenia. METHODS: Cox regression analysis was used to evaluate associations between sarcopenia and subsequent hospitalizations for infections. The long-term risk of hospitalization for infections in different sarcopenia statuses was also examined. RESULTS: During the follow-up period (median, 13.54 years), 26,769 participants were hospitalized for infections, of whom 2357 (8.8%) had probable sarcopenia and 60 (0.2%) had sarcopenia. In the fully adjusted model, sarcopenia [hazard ratio (HR), 1.62; 95% confidence interval (CI), 1.25-2.08] and probable sarcopenia (HR, 1.40; 95% CI, 1.34-1.47) at baseline were prospectively associated with the risk of hospitalization for any infection. Sarcopenia was strongly associated with gastrointestinal infections (HR, 2.69; 95% CI, 1.27-5.68), whereas probable sarcopenia was associated with liver infections (HR, 1.76; 95% CI, 1.22-2.54). The average numbers of hospitalizations for infection were significantly higher in the probable sarcopenia and sarcopenia groups than in the non-sarcopenia group (P < .001 and P < .020, respectively). No significant difference was observed between the probable and confirmed sarcopenia groups (P = .684). CONCLUSIONS AND IMPLICATIONS: Sarcopenia may help identify people at risk of hospitalization for infections, supporting the strategies for enhancing infection prevention among individuals with sarcopenia.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.