Figure S1-S10 from Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation

Résumé fourni par la source

Supplementary Figure 1. GBM-infiltrating Neutrophils are immunosuppressive cells. Supplementary Figure 2. CD71 identifies a cluster of hypoxic and glycolytic Neutrophils. Supplementary Figure 3. CD71+ Neutrophils are long-lived and mature cells that are found in the hypoxic-glycolytic niches of brain tumors. Supplementary Figure 4. CD71+ Neutrophils are immunosuppressive cells within the GBM TME. Supplementary Figure 5. CD71 expression and the immunosuppressive ability cannot be induced in CD71− Neutrophils. Supplementary Figure 6. Hypoxic CD71+ Neutrophils are long-lived cells but CD71 is not required for their immunosuppressive ability. Supplementary Figure 7. Hypoxia boosts the glycolytic metabolism of CD71+ Neutrophils. Supplementary Figure 8. Extracellular lactate and histone acetylation are not involved in the regulation of the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 9. Isosafrole specifically inhibits the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 10. Human CD71+ neutrophils are glycolytic and immunosuppressive cells.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.