Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume
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Le résumé fourni par la source
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregional volumes between pediatric bipolar disorder patients with (P-PBD) and without psychotic symptoms (NP-PBD). METHODS: Participants including 28 P-PBD, 26 NP-PBD, and 18 healthy controls (HCs) underwent structural magnetic resonance imaging (sMRI) scanning using a 3.0T MRI scanner. All T1-weighted imaging data were processed by FreeSurfer 7.4.0 software. The volumetric differences of thalamic subregions among three groups were compared by using analyses of covariance (ANCOVA) and post-hoc analyses. Additionally, we applied a standard support vector classification (SVC) model for pairwise comparison among the three groups to identify brain regions with significant volumetric differences. RESULTS: The ANCOVA revealed that significant volumetric differences were observed in the left pulvinar anterior (L_PuA) and left reuniens medial ventral (L_MV-re) thalamus among three groups. Post-hoc analysis revealed that patients with P-PBD exhibited decreased volumes in the L_PuA and L_MV-re when compared to the NP-PBD group and HCs, respectively. Furthermore, the SVC model revealed that the L_MV-re volume exhibited the best capacity to discriminate P-PBD from NP-PBD and HCs. CONCLUSION: The present findings demonstrated that reduced thalamic subregional volumes in the L_PuA and L_MV-re might be associated with psychotic symptoms in PBD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume
- Date Crossref
- 03/06/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Children's Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital Zhejiang University pays non établi dans la noticeÉtablissement de santé
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Zhejiang University Department of Child Psychology pays non établi dans la noticeUniversité ou école supérieure
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Shandong First Medical University pays non établi dans la noticeUniversité ou école supérieure
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Central South University Mental Health Institute pays non établi dans la noticeUniversité ou école supérieure
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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Faculty of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Radiology pays non établi dans la noticeUniversité ou école supérieure
Children's Hospital of Zhejiang University, First Affiliated Hospital Zhejiang University et Department of Child Psychology — Zhejiang University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.