The efficacy and safety of stem cell therapy for ischemic stroke: a systematic review and network meta-analysis study
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND AIM: Using a network meta-analysis, this study evaluates the clinical efficacy and safety of different types of stem cell therapy in regard to the recovery of neurological function, motor function, and daily living ability in ischemic stroke patients. METHODS: A computerized search of the Cochrane Library, PubMed, Web of Science, Google Scholar, CNKI, and Wanfang Database was performed to collect randomized controlled clinical studies published from the time of library construction to December 2024, on the use of stem cells to improve function in patients with ischemic stroke. RESULTS: A total of 19 studies and 1055 patients were included, comprising five stem cell types: bone marrow mononuclear cells (BMMNC), bone marrow mesenchymal stem cells (BMSC), progenitor cells (PC), peripheral blood stem cells (PBSC), and umbilical cord blood mesenchymal stem cells (UBMSC). A network meta-analysis showed that, in terms of National Institute of Health Stroke Scale (NIHSS) scores, the ranked results of different stem cell transplants were: UBMSC [69.4%] > PBSC 29.2%] > BMSC [0.8%] > PC [0.6%] > BMMNC [0.0%] > CRT [0.0%]. In terms of Modified Rankin Scale (mRS) scores, the ranked results of different stem cell transplants were: BMMNC [66.8%] > PBSC [31.7%] > PC [1.3%] > BMSC [0.2%] > CRT [0%]. In terms of Modified Barthel Index (MBI) scores, the ranked results of different stem cell transplants were: BMMNC [56.3%] > PC [34.2%] > BMSC [9.5%] > CRT [0%]. In terms of Fugl-Meyer Assessment (FMA) scores, the results of the ranking of different stem cell transplants were: BMMNC [79.3%] > BMSC [17.3%] > UBMSC [3.4%] > CRT [0%]. CONCLUSION: UBMSC had the best efficacy in repairing neurological function in patients with ischemic stroke. BMMNC had the best efficacy in improving motor function and daily living ability in patients with ischemic stroke. BMMNC had a superior overall effect.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The efficacy and safety of stem cell therapy for ischemic stroke: a systematic review and network meta-analysis study
- Date Crossref
- 31/05/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Shandong Provincial Hospital pays non établi dans la noticeÉtablissement de santé
-
Qilu Hospital of Shandong University pays non établi dans la noticeÉtablissement de santé
-
Jinan Maternity And Care Hospital pays non établi dans la noticeÉtablissement de santé
-
Shandong University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Soochow University Department of Rehabilitation Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Wuxi Ninth People's Hospital pays non établi dans la noticeÉtablissement de santé
-
Children's Hospital Affiliated to Shandong University& Jinan Children's Hospital pays non établi dans la noticeUniversité ou école supérieure
-
Jinan Vocational College of Nursing pays non établi dans la noticeUniversité ou école supérieure
-
College of Rehabilitation Medicine Ergonomics and Vocational Rehabilitation Lab pays non établi dans la noticeUniversité ou école supérieure
Shandong Provincial Hospital, Qilu Hospital of Shandong University et Jinan Maternity And Care Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.