Status Epilepticus in Adults

Le résumé fourni par la source

Abstract Status epilepticus (SE) is a neurological emergency which may lead to potentially serious morbidity and mortality; timely medical management and stepwise medical treatment are advocated. While available evidence regarding the first two lines of treatment (benzodiazepines, then intravenous antiseizure medications) relies on several randomized clinical trials, subsequent treatment mostly relies on case series and expert opinions. This chapter describes pathophysiology, current definition, epidemiology, aetiologies, and diagnosis of SE, and discusses treatment approaches and outcomes. Particular attention has been devoted to the pharmacological aspects of treatment. It concludes by highlighting that SE should thus be considered a major epileptogenic insult and prolonged anti-seizure medication treatment considered, at least initially, after its resolution. Subsequent SE recurrence is not uncommonly encountered; however, it does not seem associated with a poor prognosis, probably reflecting less severe causes.

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