In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
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Le résumé fourni par la source
Herein, 4D-flow MRI was performed on the bilateral carotid arteries in a rat model of unilateral carotid artery injury to analyze changes in flow velocity, flow rate, wall shear stress (WSS), and cross-sectional area due to endothelial injury. MR images of the rat carotid artery were acquired using 7T-MRI. Seven control rats and 16 rats with right endothelial injury (VED) were used. For five of the VED models where blood flow in both the right and left common carotid arteries was confirmed, 4D-flow MRI was performed after obtaining 3D images using the time of flight method. MRI was performed to calculate the flow velocity, flow rate, WSS, and cross-sectional area of the proximal, middle, and distal carotid arteries. In all five VED models, blood flow rate and WSS were predominantly decreased at the proximal injured side compared to the ipsilateral control side (p < 0.05). The cross-sectional area of the vessel distal to the injured side of the VED model was reduced compared to that of the non-injured side (p < 0.05). A comparison of the proximal part of the uninjured side between the control group and VED model showed that the vascular cross-sectional area was predominantly increased in the VED model (p < 0.05). 4D-flow MRI with 7T-MRI enabled analysis of changes in flow velocity, flow rate, WSS, and cross-sectional area due to vascular endothelial injury.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- In-vivo assessment of vascular endothelial injury in a rat model of unilateral carotid artery injury using 4D-flow MRI
- Date Crossref
- 27/05/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osaka Health Science University pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka Department of Medical Physics and Engineering pays non établi dans la noticeUniversité ou école supérieure
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National Cerebral and Cardiovascular Center pays non établi dans la noticeÉtablissement de santé
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Morinomiya University of Medical Sciences Department of Radiological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Osaka University of Human Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Allied Health Sciences Course of Medical Physics and Engineering pays non établi dans la noticeUniversité ou école supérieure
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National Cardiovascular and Cerebral Research Center Department of Advanced Medical Technologies pays non établi dans la noticeStructure de recherche
Osaka Health Science University, Department of Medical Physics and Engineering — The University of Osaka et National Cerebral and Cardiovascular Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.