Peripheral and cutaneous T-cell lymphomas in the United States: A 21-year mortality analysis (1999-2020).
Rattachement africain : pk, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
e19055 Background: Peripheral and cutaneous T-cell lymphomas (PTCL and CTCL) comprise of a vast variety of rare and heterogeneous subtypes of non-Hodgkin lymphomas, accounting for almost 15-20% of all lymphomas, with poor prognoses and limited treatment options. The study aims to explore 20-year mortality trends which might help in identifying vulnerable populations and addressing inequities ultimately leading to better survival rates. Methods: We conducted an examination of death certificates sourced from the CDC WONDER database (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) from 1999 to 2020. Mortality rate due to peripheral and cutaneous T-cell lymphomas was assessed using the ICD code C84. Age-Adjusted Mortality Rates (AAMRs) per 100,000 persons, Average Annual Percentage Change (AAPC) and Annual Percent Change (APC) were reported. APCs in AAMRs with 95% CI were obtained using joint point regression analysis across different demographic and geographic subgroups. Results: The AAMR for Peripheral and Cutaneous T-cell lymphomas increased from 0.234 (upper CI=95%; 0.216 to 0.253) in 1999 to 0.343 (upper CI=95%; 0.324 to 0.362) in 2020 with an APC of 4.76% from 1999-2006, followed by an increase of 1.09% from 2006-2020 (p<0.000001). Females exhibited higher AAMRs than males (p= 0.04). Large central metropolitan areas had an increased AAPC (2.647) followed by non-metropolitan areas (AAPC=1.504). The 75-84 year age group reported the highest mortality with 5967 deaths (AAPC=3.747) whereas lower death rates were reported by younger age groups. The North-east reported the highest AAMR (0.392; 95% upper CI, 0.344 to 0.44) followed by South (0.313; upper CI=95%, 0.306 to 0.32), West (0.313; upper CI=95%, 0.304 to 0.322) and mid-West (0.312; upper CI=95%, 0.303 to 0.321). The Black or African American reported the highest AAMR and an APC of 1.908%, p= 0.000032. Pennsylvania had the highest APC (2.881%) whereas a decrease in mortality was observed in California after 2010 (APC=-1.410%,p=0.000013). Conclusions: Over the last two decades, there has been an overall increase in the mortality rate due to peripheral and cutaneous T-cell lymphomas in the United States. Increased AAMRs have been reported by females, older age groups, metropolitan areas, Black or African Americans, North-west regions and states like Pennsylvania representing various disparities among the trends. Interestingly, California reported a decreased mortality during the last decade. These variations in the trends necessitate the need for additional exploration and targeted interventions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Peripheral and cutaneous T-cell lymphomas in the United States: A 21-year mortality analysis (1999-2020).
- Date Crossref
- 01/06/2025
- Éditeur
- American Society of Clinical Oncology (ASCO)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King Edward Medical University pays non établi dans la noticeUniversité ou école supérieure
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Services Institute of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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CMH Lahore Medical College and Institute of Dentistry pays non établi dans la noticeÉtablissement de santé
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Moffitt Cancer Center pays non établi dans la noticeÉtablissement de santé
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American University pays non établi dans la noticeUniversité ou école supérieure
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Georgetown College pays non établi dans la noticeUniversité ou école supérieure
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Shaikh Zayed Postgraduate Medical Institute pays non établi dans la noticeÉtablissement de santé
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FMH College of Medicine and Dentistry pays non établi dans la noticeUniversité ou école supérieure
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Quaid-e-Azam Medical College pays non établi dans la noticeUniversité ou école supérieure
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Shaikh Khalifa Bin Zayed Al Nahyan Medical and Dental College pays non établi dans la noticeUniversité ou école supérieure
King Edward Medical University, Services Institute of Medical Sciences et CMH Lahore Medical College and Institute of Dentistry, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.