Identification and functional analysis of GNAI1 as a biomarker associated with immune-related genes in pediatric acute myeloid leukemia
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Le résumé fourni par la source
Background: Immunotherapy is a pivotal approach in combating acute myeloid leukemia (AML), with the identification of immunomarkers being imperative. This investigation aimed to delineate biomarkers linked with immune-related genes (IRGs) in AML, thereby providing a theoretical framework for AML therapeutics. Methods: This research utilized AML-specific datasets [GSE9476 and The Cancer Genome Atlas (TCGA)-AML] alongside 1,793 IRGs. Initially, weighted gene co-expression network analysis (WGCNA) was employed to identify module genes using an integrative and systematic methodology. Differential gene expression analyses were conducted on GSE9476 and aggregated AML data from the University of California Santa Cruz (UCSC) Xena platform, alongside the Genotype-Tissue Expression (GTEx) database, to identify differentially expressed genes (DEGs). These DEGs were then intersected with WGCNA module genes and IRGs to isolate potential candidate genes. Kaplan-Meier (K-M) survival curves were subsequently utilized to identify pivotal genes with significant survival disparities. The prognostic significance of these genes was further assessed through both univariate and multivariate Cox regression analyses to pinpoint biomarkers. Finally, analyses focusing on functional enrichment associated with the identified biomarkers. Results: . Conclusions: , associated with IRGs in AML, was identified as a biomarker, providing a basis for understanding AML pathogenesis and offering new avenues for therapeutic strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Identification and functional analysis of GNAI1 as a biomarker associated with immune-related genes in pediatric acute myeloid leukemia
- Date Crossref
- 01/05/2025
- Éditeur
- AME Publishing Company
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kunming Medical University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
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Qujing Normal University pays non établi dans la noticeUniversité ou école supérieure
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Kunming Children's Hospital Department of Hematology pays non établi dans la noticeÉtablissement de santé
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Dali University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Southwest Medical University Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Qujing Medical College Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
Department of Hematology — Kunming Medical University, Qujing Normal University et Department of Hematology — Kunming Children's Hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.