Can INSM1 and Phox2B be an Alternative to Conventional Neuroendocrine Markers in the Diagnosis of Pancreatic Solid Pseudopapillary Neoplasia and Neuroendocrine Tumors?

Le résumé fourni par la source

Introduction: Solid pseudopapillary neoplasm (SPN) and pancreatic neuroendocrine tumors (PNET) often present diagnostic challenges due to their overlapping clinical and histopathological features.We aimed to investigate the possible role of paired-like homeobox 2B (Phox2B) in this differentiation.Methods: This study included 12 patients diagnosed with PNET and 7 patients diagnosed with SPN.Clinicopathologic data were collected and immunohistochemical staining was performed for Phox2B, synaptophysin (SYN), chromogranin-A (CHR), and insulinoma-associated protein 1 (INSM1).Results: Phox2B exhibited limited positivity in PNET (8.3%) and rare focal staining in SPN (considered as negative).Moderate to strong immunoreactivity with SYN and CHR was observed in all PNET cases, while SPN cases showed weak to moderate SYN expression but no staining with CHR.INSM1 showed positive staining in all PNET cases and no staining in SPN cases.Conclusion: No significant correlation was observed between Phox2B and INSM1 expressions and clinicopathologic parameters.While INSM1 serves as a reliable marker in supporting the diagnosis of neuroendocrine neoplasia in the differential diagnosis of PNET and SPN, Phox2B does not exhibit comparable diagnostic utility.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.