Evidence for the Link Between Non-Motor Symptoms, Kinematic Gait Parameters, and Physical Function in People with Parkinson’s Disease

Le résumé fourni par la source

BACKGROUND: Parkinson's disease (PD) affects both motor and non-motor functions, but their interactions are understudied. This study aims to explore the relationships between non-motor and motor effects of PD, focusing on depression, fatigue, gait parameters, concentration, and physical function. METHODS: This is a secondary analysis of baseline data from a randomized feasibility study using a commercially available Heel2Toe™ sensor, providing auditory feedback for gait quality. The sample included PD patients with gait impairments who walked without aids. Non-motor measures were depression, fatigue, and concentration, while motor measures included gait quality (angular velocity and variability during heel strike, push-off, foot swing) and physical function (6MWT, Mini-BESTest, Neuro-QoL). Path analysis was used to assess direct and indirect effects. RESULTS: Among 27 participants, fatigue impacted heel strike, which affected Neuro-QoL. Mood influenced push-off and Neuro-QoL, with a direct link to 6MWT. Foot swing affected Mini-BESTest and Neuro-QoL directly. CONCLUSIONS: Non-motor PD effects directly influenced specific gait parameters and physical function indicators, highlighting potential digital biomarkers of fatigue and mood for targeted interventions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.